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Polypodium Leucotomos      Hay evidencia de que las formulaciones a base de la variedad de  Phlebodium decumanum, orgánicamente cultivado y procesado en la factoría del lago Yojoa, pueden ser de gran valor en la mejoría de la calidad de vida, y en la evolución de la enfermedad, en situaciones donde una disfunción inmune  esté relacionada con la sobreproducción de citokinas.

        El Phlebodium decumanum reúne los requerimientos actuales de alimento funcional o nutricéutico, por la combinación de su efecto nutricional con la acción beneficiosa sobre una o varias  funciones específicas en el organismo: reversión de la disfunción inmune involucrada en el Síndrome de Sobrentrenamiento y Fatiga Crónica.

      Diferentes formulaciones conteniendo una fracción hidrosoluble, purificada y estandarizada  de los frondes, registrada como EXPLY-37, han sido desarrolladas y usadas como suplementos nutricionales. Estas formulaciones han mostrado actividad en la reversión en el Síndrome de Sobrentrenamiento y Fatiga Crónica.

      El Phlebodium decumanum  ha mostrado actividad en la reversión del síndrome de Sobrentrenamiento  en atletas y demás personas practicantes de deportes. Este producto puede también ser usado en personas que sufren del Síndrome de Fatiga Crónica (CFS).

Sports performance, oxidative metabolism and immune function: Effects of Phlebodium decumanum (EXPLY).
De Teresa, C., Alcaide A., Huertas J.R., Fresno M.
(Centro Andaluz de Medicina del Deporte, Granada y Centro de Biología Molecular Severo Ochoa, Universidad Autónoma, Madrid) II Congress of the European Federation of Sports Medicine.  

        Abstract: TCycling is a sport characterized by special energy requirements due to the high  competition demands:  daily, high energy expenditure stages for 1 to 3 weeks without  sufficient recovery  periods. Overcharge, muscle fatigue and overtraining syndrome are common among cyclists and are associated to a pattern of immune disfunction characterized by overexpression of  pro-inflammatory cytokines. EXPLY-37 is a purified and standardized water-soluble fraction obtained from the leaves of   Phlebodium decumanum, a fern organically cultivated and processed  in the Yojoa lake pure monocultures (Honduras). Different formulations containing EXPLY-37  have  shown a modulating effect on the release of TNF induced in different cell lines by various stimulii. The aim of this study was to investigate the effect of Phlebodium decumanum on cycling performance and to explore the eventual correlation with the prevention of oxidative stress and immune disfunction.   18 cyclists were submitted to intensive aerobic training. They randomly received either Phlebodium decumanum, as a nutritional supplement,  or placebo for 4 weeks. Parameters related to performance, oxidative damage and immune disfunction were compared at T1 (4 week training) and  T0 (basal).  Overall performance was improved in the group receiving Phlebodium decumanum, as shown by the increase in maximal aerobic work (watts) (367.5±16.87 vs 340±17.48, p=0.0005)  maximal  respiratory quotient (1.43±0.20 vs 1.25±0.05, p=0.05) and maximal lactate concentration (mmol/L) (11.64±1.5 vs 10.15±1.68, p=0.0005).    These data are analyzed in connection with those related to the enhancement of oxidative metabolism (plasma CoQ10 and a-tocopherol levels) and to the prevention of oxidative stress (mitochondrial lymphocyte DNA damage). They appear to be  in close relationship with the  activity of Phlebodium decumanum in the regulation of certain cytokines and their receptors involved in the inflammatory response associated to the overtraining syndrome, and support the use of EXPLY-37 formulations as nutritional supplements in the prevention of overcharge, muscle fatigue and overtraining.
        La eficacia de estas formulaciones debe ser relacionada con la propiedad del Phlebodium decumanum, en la modulación de la liberación de ciertas citokinas proinflamatorias tales como TNF. Pulse aquí.

In vitro anti-inflammatory activity of Phlebodium decumanum. Modulation of tumor necrosis factor and soluble TNF receptors .

        De Carmen Punzón (1), Antonio Alcaide (2) and Manuel Fresno(1).

Received 19 July 2002; revised 19 March 2003; accepted 18 April 2003. ; Available online 15 May 2003.

      Abstract: The immunomodulatory activity of a standardized water soluble fraction of the fern Phlebodium decumanum (EXPLY-37®) previously shown to have "in vivo" anti-inflammatory activity was analyzed "in vitro". This extract inhibited tumor necrosis factor (TNF) production by macrophages activated with lipopolysaccharide (LPS) or LPS plus interferon (IFN)- . In contrast, nitric oxide (NO) and interleukin (IL)-1 production were not affected in the same cultures, whereas IL-6 production was partially inhibited. More interestingly, EXPLY-37® increased the release of soluble TNF-receptor 2 (sTNFR2) and of IL-1R antagonist (IL-1Ra) but not of sTNFR1, by activated macrophages. EXPLY-37® had no effect on T lymphocyte activation, measured as proliferation as well as expression of early and late cell surface antigens CD69, CD25 (IL-2R- ) and CD71 (transferrin receptor) at the cell membrane. At the molecular level, EXPLY-37® did not inhibit the activation of the nuclear factor kappa B (NF- B) transcription factor by TNF. In summary, EXPLY-37® has two anti-inflammatory activities "in vitro": it decreases TNF production and increases IL-1Ra and sTNFR2, which may be able to neutralize IL-1 and TNF activity, respectively.

Author Keywords: Phlebodium decumanum; Anti-inflammatory activity; Cytokine; Cytokine receptor; Macrophages; T lymphocytes
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(1) Centro de Biología Molecular (CBM), Universidad Autónoma de Madrid, Spain

(2) HELSINT S.A.L., Granada, Spain
International Immunopharmacology.

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